CCR8 Antibody

Immunohistochemistry-Paraffin: CCR8 Antibody [NB100-710] - Paraffin section of human spleen.

Product Discontinued

CCR8 Antibody Summary

• Immunogen: Synthetic peptide CYSFYNQQTLK corresponding to second extracellular domain sequence of human CCR8.
• Localization: Cell Membrane
• Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCR8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:37500
  • Immunohistochemistry 1:150
  • Immunohistochemistry-Paraffin 1:150
  • Western Blot 1:1000
• Application Notes: Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
• Control:

  K-562 Whole Cell Lysate

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CCR8 Antibody

• CC chemokine receptor 8
• C-C CKR-8
• CC-chemokine receptor chemr1
• CC-CKR-8
• CCR8
• CCR-8
• CD198
• CDw198 antigen
• CDw198
• chemokine (C-C motif) receptor 8
• chemokine (C-C) receptor 8
• chemokine (C-C) receptor-like 2
• Chemokine receptor-like 1
• ChemR1
• CKRL1
• CKR-L1
• CKRL1MGC129966
• CMKBR8MGC129973
• CMKBRL2C-C chemokine receptor type 8
• CY6
• GPRCL1
• GPRCY6
• GPR-CY6
• TER-1
• TER1CC chemokine receptor CHEMR1

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation regulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. CCR* is also believed to be alternative coreceptor with CD4 for HIV-1 infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCR8
• Entrez:
  • 1237(Human)