CCR3 Antibody - BSA Free

Immunohistochemistry-Paraffin: CCR3 Antibody [NB100-700] - NB100-700 antibody to mouse CCR3 on paraffin section of mouse spleen.

Product Discontinued

CCR3 Antibody - BSA Free Summary

• Immunogen: Synthetic peptide: TDEIKTVVESFETTPYEYEWAPPC, corresponding to N terminal amino acids 5-28 of Mouse CCR3
• Localization: Integral membrane protein
• Specificity: Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCR3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:125
  • Immunohistochemistry-Paraffin 1:125
  • Western Blot 1:500
• Application Notes: IHC-P: Antigen retrieval is not essential but may optimize staining. Optimal dilutions/concentrations should be determined by the end user. All dilutions given are minimums.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4 and 0.14M NaCl
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCR3 Antibody - BSA Free

• b-chemokine receptor
• CC chemokine receptor 3
• C-C chemokine receptor type 3
• C-C CKR-3
• CCR3
• CCR-3
• CD193 antigen
• CD193
• chemokine (C-C motif) receptor 3
• CKR3CC-CKR-3CMKBR3CD193
• eosinophil CC chemokine receptor 3
• Eosinophil eotaxin receptor
• MGC102841

Background

CCR3 is a receptor for CC chemokine eotaxin-1 and eotaxin-2. CCR3 has been reported in blood, brain, lung, bone marrow, kidney, liver, lymph node, placenta, skin, spleen, thymus, thyroid, uterus, and vessel. Within these tissues, CCR3 is expressed in specific cell types, including eosinophils, basophils, Th2 cells, and mast cells. The agonists for CXCR3 (IP-10, mig, and I-TAC) act as antagonists for CCR3 by competing for the binding of eotaxin to CCR3. The 356 amino acid CCR3 receptor is expressed on human eosinophils, basophils, neutrophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a key role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and -2 and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types. The CCR3 receptor has been reported to be upregulated by high affinity Fc IgE receptor ligation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCR3
• Entrez:
  • 1232(Human)