CCR2 Antibody - BSA Free

Immunohistochemistry-Paraffin: CCR2 Antibody [NB100-718] - Section of human spleen.

• Reactivity: Hu
• Applications: WB, ELISA, IHC, IHC-P
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

CCR2 Antibody - BSA Free Summary

• Immunogen: Synthetic peptide C-G17EEVTTFFDYDYGAPCHKFDVKQ39 corresponding to the N-terminal extracellular domain of human CCR2.
• Localization: Cell Membrane
• Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:30000
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
  • Western Blot 1:500
• Control:

  Blood Leukocyte Whole Cell Lysate
  Human Spleen Whole Tissue Lysate (Adult Whole Normal)
  CCR2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4 and 0.14M NaCl
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCR2 Antibody - BSA Free

• C-C chemokine receptor type 2
• C-C CKR-2
• CC-CKR-2
• CC-CKR-2CKR2B
• CCR2
• CCR-2
• CCR2A
• CCR2B
• CD192 antigen
• CD192
• chemokine (C-C motif) receptor 2
• CKR2
• CKR2A
• CMKBR2
• CMKBR2MGC111760
• FLJ78302
• MCP-1 receptor
• MCP-1-R
• MCP-1-RMGC103828
• MGC168006
• Monocyte chemoattractant protein 1 receptor
• monocyte chemotactic protein 1 receptor

Background

CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR2 Antibody (NB100-718)(1)

Publication using NB100-718

• Sakamoto T, Ishibashi T, Sakamoto N et al. Endogenous NO blockade enhances tissue factor expression via increased Ca2+ influx through MCP-1 in endothelial cells by monocyte adhesion. Arterioscler Thromb Vasc Biol;25(9): 2005-11. 2005-09-01 [PMID: 16020745] (WB, Human)

Bioinformatics

• Gene Symbol: CCR2
• Entrez:
  • 729230(Human)