CCR2 Antibody (3G7)

Images

 
Western Blot: CCR2 Antibody (3G7) [NBP2-35334] - Western blot analysis of CCR2 [3G7] in Molt4 lysate.
Immunohistochemistry-Paraffin: CCR2 Antibody (3G7) [NBP2-35334] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human breast using CCR2 antibody (clone 3G7) at 5 ug/ml concentration. The glandular ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody (3G7) [NBP2-35334] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human HCC (hepatocellular carcinoma / malignant hepatoma) using CCR2 antibody (clone ...read more
Immunohistochemistry-Paraffin: CCR2 Antibody (3G7) [NBP2-35334] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human esophageal squamous cell carcinoma (SCC) using CCR2 antibody (clone 3G7) at 5 ...read more

Product Details

Summary
Reactivity Hu, Mu, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clone
3G7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CCR2 Antibody (3G7) Summary

Immunogen
A synthetic peptide made to an N-terminal portion of the human CD63 protein (between residues 1-100) [UniProt P41597]
Localization
Cell membrane
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG2b Lambda
Clonality
Monoclonal
Host
Mouse
Gene
CCR2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
Reviewed Applications
Read 1 Review rated 4
using
NBP2-35334 in the following applications:

Publications
Read Publications using
NBP2-35334 in the following applications:

  • 1 publication
  • WB
    1 publication

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 30213824).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for CCR2 Antibody (3G7)

  • C-C chemokine receptor type 2
  • C-C CKR-2
  • CC-CKR-2
  • CC-CKR-2CKR2B
  • CCR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192 antigen
  • CD192
  • chemokine (C-C motif) receptor 2
  • CKR2
  • CKR2A
  • CMKBR2
  • CMKBR2MGC111760
  • FLJ78302
  • MCP-1 receptor
  • MCP-1-R
  • MCP-1-RMGC103828
  • MGC168006
  • Monocyte chemoattractant protein 1 receptor
  • monocyte chemotactic protein 1 receptor

Background

CCR2, or C-C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR2 Antibody (NBP2-35334)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, WB.


Filter By Application
IHC-P
(1)
WB
(1)
All Applications
Filter By Species
Human
(2)
All Species

Review for CCR2 Antibody (NBP2-35334) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Other.

Reviews using NBP2-35334:
Filter by Applications
ICC
(1)
All Applications
Filter by Species
Other
(1)
All Species
Images Ratings Applications Species Date Details
Immunocytochemistry CCR2 NBP2-35334
Enlarge
4
reviewed by:
Anonymous
ICC Other 02/02/2015
View

Summary

ApplicationImmunocytochemistry
Sample Testedrabbit spleen isolated primary cells
SpeciesOther
LotA-1

Blocking

Blocking Details5% horse serum blocking for 1h at RT.

Secondary Antibody

Secondary Descriptionbiotinylated horse anti-mouse IgG.
Secondary Manufacturer Cat#Vector. BA-2000
Secondary Concentration1:400 dilution of secondary antibody.

Details

Detection NotesDAB as chromogenic agent. Develop for 5min at RT. Use hematoxylin stain 30 seconds for counterstain.
Fixation Details4% paraformaldehyde for 30min. 10ug/ml Proteinase K treated 20min for retrieval at RT.
Wash Description0.01M PBS(PH7.4) wash three times after each step.

Product General Protocols

View specific protocols for CCR2 Antibody (NBP2-35334): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CCR2 Antibody (NBP2-35334) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-35334AF350
Alexa Fluor 405 NBP2-35334AF405
Alexa Fluor 488 NBP2-35334AF488
Alexa Fluor 532 NBP2-35334AF532
Alexa Fluor 594 NBP2-35334AF594
Alexa Fluor 647 NBP2-35334AF647
Alexa Fluor 700 NBP2-35334AF700
Alexa Fluor 750 NBP2-35334AF750
Biotin NBP2-35334B
DyLight 350 NBP2-35334UV
DyLight 405 NBP2-35334V
DyLight 488 NBP2-35334G
DyLight 550 NBP2-35334R
DyLight 594 NBP2-35334DL594
DyLight 650 NBP2-35334C
DyLight 680 NBP2-35334FR
DyLight 755 NBP2-35334IR
FITC NBP2-35334F
HRP NBP2-35334H
Janelia Fluor 549 NBP2-35334JF549
Janelia Fluor 646 NBP2-35334JF646

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Bioinformatics Tool for CCR2 Antibody (NBP2-35334)

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Research Areas for CCR2 Antibody (NBP2-35334)

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Blogs on CCR2.

Rest in Peace: Is the Receptor Interacting Protein (RIP) Kinase-3 (RIPK3) a Protector or Offender?
By Jamshed Arslan, Pharm. D., PhD. Receptor interacting protein kinases (RIPKs) in necroptosisDeath is perhaps inevitable. Cell death can be programed and immunologically silent (apoptosis), unprogrammed and inflamm...  Read full blog post.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

CCR2: Affecting Autoimmunity via MCP1 interactions
CCR2, also known as CD192 (cluster of differentiation 192), is a chemokine receptor and is expressed by monocytes, activated T cells, B cells and natural killer cells. This protein is encoded by CCR2 gene in humans. CCR2 gene encodes two protein isofo...  Read full blog post.

MCP1: One Chemoattractant that's Hard to Resist
Monocyte Chemoattractant Protein (MCP1) is a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migrati...  Read full blog post.

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Recent Reviews

4
5
0
4
1
3
0
2
0
1
0

Anonymous
02/02/2015
Application: ICC
Species: Other

Bioinformatics

Gene Symbol CCR2
Entrez
Uniprot