CCP110 Antibody

Western Blot: CCP110 Antibody [NB100-61066] - Detection of Human CEP110 on HeLa whole cell lysate using NB100-61066. CEP110 was also immunoprecipitated, albeit less efficiently, by rabbit anti-CEP110 antibody NB100-61067.

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

CCP110 Antibody Summary

• Description: Novus Biologicals Rabbit CCP110 Antibody (NB100-61066) is a polyclonal antibody validated for use in WB and IP. Anti-CCP110 Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The immunogen recognized by this antibody maps to a region between residue 575 and 625 of human centrosomal protein 110kDa using the numbering given in entry CAH18111.1 (GeneID 11064).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCP110
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 2- 5 ug/mg lysate
  • Western Blot 1:2000-1:10000

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCP110 Antibody

• centriolar coiled coil protein 110kDa
• Cep110
• CP110

Background

CEP110 is a centrosomal protein and an important component of the microtubule organizing center. CEP110 is required for centrosome duplication and is phosphorylated by cyclin dependent kinases (CDKs). The CEP110 gene has been identified as a fusion partner of the FGF receptor (FGFR) gene in stem cell myeloproliferative disorder (MPD).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCP110 Antibody (NB100-61066)(3)

Publications using NB100-61066

• Sharma SS, Ma L, Bagui TK et al. A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene 2012-08-01 [PMID: 22158041]
• Gudi R, Zou C, Li J et al. Centrobin-tubulin interaction is required for centriole elongation and stability. J Cell Biol 2011-05-01 [PMID: 21576394]
• D'Angiolella V, Donato V, Vijayakumar S et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 2010-07-01 [PMID: 20596027]

Bioinformatics

• Gene Symbol: CCP110