Reactivity | HuSpecies Glossary |
Applications | WB, Flow, IHC, CyTOF-ready |
Clonality | Polyclonal |
Host | Goat |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Activin RIA/ALK-2 Asp23-Glu123 Accession # Q04771 |
Specificity | Detects human Activin RIA/ALK‑2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Activin RIB, rhActivin RIIA, and rhActivin RIIB is observed. |
Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Goat |
Gene | ACVR1 |
Purity | Immunogen affinity purified |
Purity Statement | Antigen Affinity-purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
|
|
Publications |
|
Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Purity | Immunogen affinity purified |
Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine‑threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A), and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type I receptors are highly conserved. Human, mouse and bovine type IA activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type I receptor does not bind activin.
Secondary Antibodies |
Isotype Controls |
Diseases for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (AF637)Discover more about diseases related to Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (AF637).
| Pathways for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (AF637)View related products by pathway.
|
PTMs for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (AF637)Learn more about PTMs related to Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (AF637).
|
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.