ZNF198 Antibody

Images

 
Western Blot: ZNF198 Antibody [NB100-56490] - Western blot analysis of ZNF198 in mouse skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide using NB100-56490 at 0.1 ug/ml.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NB100-56490] - analysis of human breast using this antibody at 10 ug/ml.

Product Details

Summary
Reactivity Hu, Ca, Pm, Mu, Rt, Bv, ChSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

ZNF198 Antibody Summary

Immunogen
A portion of amino acids 1250-1300 of human Zinc finger protein 198 was used as the immunogen.
Predicted Species
Mouse (94%), Rat (94%), Chicken (94%), Bovine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ZMYM2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1-1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Reacts with Dog, Human, Monkey and Orangutan. 94% sequence identity with bovine, chicken, mouse and rat and 76% with xenopus proteins.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ZNF198 Antibody

  • FIMRAMPSCLL
  • Fused in myeloproliferative disorders protein
  • MYM
  • Rearranged in atypical myeloproliferative disorder protein
  • Zinc finger protein 198rearranged in an atypical myeloproliferative disorder
  • zinc finger, MYM-type 2
  • ZNF198zinc finger MYM-type protein 2

Background

ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ZMYM2
Entrez
Uniprot