ZNF198 Antibody - BSA Free

Western Blot: ZNF198 Antibody [NB100-56490] - Analysis of ZNF198 in mouse skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide using this antibody at 0.1 ug/ml.

Immunohistochemistry-Paraffin: ZNF198 Antibody [NB100-56490] - Analysis of human breast using this antibody at 10 ug/ml.

• Reactivity: Hu, Ca, Pm, Mu, Rt, Bv, Ch
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.5 mg/ml

ZNF198 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit ZNF198 Antibody - BSA Free (NB100-56490) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acids 1250-1300 of human Zinc finger protein 198 was used as the immunogen.
• Predicted Species: Mouse (94%), Rat (94%), Chicken (94%), Bovine (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ZMYM2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 0.1-1 ug/ml

Reactivity Notes

Xenopus proteins (76%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.2% gelatin
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ZNF198 Antibody - BSA Free

• FIMRAMPSCLL
• Fused in myeloproliferative disorders protein
• MYM
• Rearranged in atypical myeloproliferative disorder protein
• Zinc finger protein 198rearranged in an atypical myeloproliferative disorder
• zinc finger, MYM-type 2
• ZNF198zinc finger MYM-type protein 2

Background

ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ZMYM2
• Entrez:
  • 7750(Human)
  • 76007(Mouse)
  • 305913(Rat)
• Uniprot:
  • Q9UBW7(Mouse)