Recombinant Human CCL26/Eotaxin-3 Protein

SDS-Page: Human CCL26/Eotaxin-3 Protein [NBP2-34982]

• Reactivity: Hu
• Applications: PAGE, Bioactivity
• Format: Carrier-Free
• Concentration: LYOPH

Recombinant Human CCL26/Eotaxin-3 Protein Summary

• Description: A single non-glycosylated polypeptide chain containing 71 amino acid residues corresponding to CCL26/Eotaxin-3 Source: E. coli

  Uniprot ID: Q9Y258

  Amino Acid Sequence: TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L

• Details of Functionality: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CCR3 transfected HEK293 cells is in a concentration range of 0.5-2.0 ug/ml.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: CCL26
• Purity: > 97 % pure by SDS-PAGE and HPLC
• Endotoxin Note: Less than 1 EU/ug of CCL26/Eotaxin-3 as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 8.4 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: > 97 % pure by SDS-PAGE and HPLC
• Reconstitution Instructions: Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.

Alternate Names for Recombinant Human CCL26/Eotaxin-3 Protein

• CC chemokine IMAC
• C-C motif chemokine 26
• CCL26
• chemokine (C-C motif) ligand 26
• chemokine N1
• Eotaxin3
• Eotaxin-3
• Eotaxin-3/CCL26
• IMAC
• Macrophage inflammatory protein 4-alpha
• MGC126714
• MIP-4a
• MIP-4alpha
• SCYA26
• SCYA26MIP-4-alpha
• small inducible cytokine A26
• small inducible cytokine subfamily A (Cys-Cys), member 26
• Small-inducible cytokine A26
• TSC-1Thymic stroma chemokine-1

Background

CCL26 is novel CC family chemokine, also known as TARC (thymus and activation regulated chemokine). It is encoded by CCL26 gene, which is located on Chr.7 in humans, and ubiquitously expressed at low levels in various tissues including heart and ovary. CCL26 elicits its effects activity by binding to the cell surface chemokine receptor CCR3, and chemotactic for eosinophils and basophils

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: CCL26
• Uniprot:
  • Q9Y258()
  • Q9Y258()
  • Q9Y258()