Human CCL13/MCP-4 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CCL13/MCP-4 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CCL13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL13/MCP-4 DuoSet ELISA, 15 Plate

• C-C motif chemokine 13
• CCL13
• chemokine (C-C motif) ligand 13
• CKb10
• MCP4
• MCP-4
• MCP-4Monocyte chemoattractant protein 4
• MGC17134
• NCC-1Monocyte chemotactic protein 4
• NCC1Small-inducible cytokine A13
• new CC chemokine 1
• SCYA13CK-beta-10
• SCYL1
• small inducible cytokine subfamily A (Cys-Cys), member 13

Background

Human MCP-4, also known as CCL13, encodes a 98 amino acid (aa) precursor protein with a 23 aa hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature MCP-4. Mature MCP-4 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins.

Publications for CCL13/MCP-4 (DY327)(12)

Publications using DY327

• Brollo, M;Salvator, H;Grassin-Delyle, S;Glorion, M;Descamps, D;Buenestado, A;Naline, E;Tenor, H;Tiotiu, A;Devillier, P; The IL-4/13-induced production of M2 chemokines by human lung macrophages is enhanced by adenosine and PGE2 International immunopharmacology 2024-01-23 [PMID: 38266451] (Human)
• SI Johanns, RG Gantin, B Wangala, K Komlan, WA Halatoko, M Banla, P Karabou, AJ Luty, H Schulz-Key, C Köhler, PT Soboslay Onchocerca volvulus-specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo PloS Neglected Tropical Diseases, 2022-05-03;16(5):e0010340. 2022-05-03 [PMID: 35503786] (Human)
• W Francuzik, K Pažur, M Dalke, S Dölle-Bier, M Babina, M Worm Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis JCI Insight, 2022-04-08;0(0):. 2022-04-08 [PMID: 35202004] (Human)
• B Grüner, L Peters, A Hillenbran, P Vo beta berg, J Schweiker, EG Rollmann, LH Rodriguez, J Blumhardt, S Burkert, P Kern, C Köhler, PT Soboslay Echinococcus multilocularis specific antibody, systemic cytokine, and chemokine levels, as well as antigen-specific cellular responses in patients with progressive, stable, and cured alveolar echinococcosis: A 10-year follow-up PloS Neglected Tropical Diseases, 2022-02-02;16(2):e0010099. 2022-02-02 [PMID: 35108275] (Human)
• X Li, D Guo, Y Hu, Y Chen Oxidative Stress and Inflammation Are Associated with Coexistent Severe Multivessel Coronary Artery Stenosis and Right Carotid Artery Severe Stenosis in Elderly Patients Oxidative Medicine and Cellular Longevity, 2021-12-22;2021(0):2976447. 2021-12-22 [PMID: 34976297] (Human)
• Himes B, Koziol-White C, Johnson M, Nikolos C, Jester W, Klanderman B, Litonjua A, Tantisira K, Truskowski K, MacDonald K, Panettieri R, Weiss S Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma. PLoS ONE, 2015-07-24;10(7):e0134057. 2015-07-24 [PMID: 26207385] (Human)
• Lechner C, Komander K, Hegewald J, Huang X, Gantin R, Soboslay P, Agossou A, Banla M, Kohler C Cytokine and chemokine responses to helminth and protozoan parasites and to fungus and mite allergens in neonates, children, adults, and the elderly. Immun Ageing, 2013-07-15;10(1):29. 2013-07-15 [PMID: 23855879] (Human)
• Krausgruber T, Blazek K, Smallie T IRF5 promotes inflammatory macrophage polarization and T(H)1-T(H)17 responses. Nat. Immunol., 2011-01-16;12(3):231-8. 2011-01-16 [PMID: 21240265] (Human)
• Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, Oturai A, Sorensen PS, Lorentzen AR, Celius EG, Leppa V, Koivisto K, Tienari PJ, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Genes Immun., 2009-10-29;11(2):142-54. 2009-10-29 [PMID: 19865101] (Human)
• Yanaba K, Yoshizaki A, Muroi E, Hara T, Ogawa F, Shimizu K, Hasegawa M, Fujimoto M, Takehara K, Sato S CCL13 is a promising diagnostic marker for systemic sclerosis. Br. J. Dermatol., 2009-09-11;162(2):332-6. 2009-09-11 [PMID: 19747218] (Human)
• Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eur. Respir. J., 2009-07-30;35(3):540-8. 2009-07-30 [PMID: 19643942] (Human)
• Hintzen C, Quaiser S, Pap T, Heinrich PC, Hermanns HM Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. Arthritis Rheum., 2009-07-01;60(7):1932-43. 2009-07-01 [PMID: 19565514] (Human)

FAQs for CCL13/MCP-4 (DY327). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CCL13