CCL2/MCP1 Antibody (MNA1) Summary
The antibody reacts with both human natural and recombinant MCP1 in ELISA.
The antibody reacts with both human natural and recombinant MCP1 in ELISA. MCP1 is a member of the CC subfamily of chemokines. MCP1 is a proinflammatory cytokine which acts both as an activation factor and as chemokine for monocytic cells. The antibody inhibits the biological activity of natural and recombinant human MCP1. The antigen specificity was assessed by ELISA. The antigen specificity was further assessed by immunoprecipitation and western blot. No crossreactivities with other cytokines have been detected.
Protein A or G purified
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- Western Blot 1:100-1:2000
- Blocking/Neutralizing 50-200 molar excess
- ELISA 1:100-1:2000
- Flow Cytometry 1:10-1:1000
- Immunocytochemistry/Immunofluorescence 1:10-1:500
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
- Immunoprecipitation 1:10-1:500
May also cross react with Porcine.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS containing 0.1% BSA.
Protein A or G purified
Alternate Names for CCL2/MCP1 Antibody (MNA1)
- C-C motif chemokine 2
- chemokine (C-C motif) ligand 2
- HC11Monocyte secretory protein JE
- MCAFMonocyte chemotactic and activating factor
- MCP1 Monocyte chemotactic protein 1
- MCP-1 Small-inducible cytokine A2
- Monocyte chemoattractant protein 1
- monocyte chemoattractant protein-1
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous tomouse Sig-je)
- small inducible cytokine subfamily A (Cys-Cys), member 2
Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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