Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IP, B/N
• Clone: 352213
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Carnosine Dipeptidase 1/CNDP1
  Pro28-His507
  Accession # Q96KN2
• Specificity: Detects human Carnosine Dipeptidase 1/CNDP1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Neutralization

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor® 350]

• beta-Ala-His dipeptidase
• Carnosinase 1
• carnosine dipeptidase 1 (metallopeptidase M20 family)
• Carnosine Dipeptidase 1
• CN1MGC102737
• CNDP dipeptidase 1
• CNDP1
• CPGL2
• CPGL2MGC142072
• EC 3.4.13.20
• Glutamate carboxypeptidase-like protein 2
• HsT2308
• MGC10825
• Serum carnosinase

Background

The human CNDP1 gene encodes carnosine dipeptidase 1, a member of the M20 family of metalloproteases (1, 2). Also known as X-His dipeptidase, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), CNDP1 is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa = beta -Ala (carnosine) and Xaa = gamma -aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter fucntions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase. CNDP1 consists of a signal peptide (residues 1 to 26) and the mature chain (residues 27 to 507). The amino acid sequence of human CNDP1 is 97%, 85%, 82% and 67% identical to that of chimpanzee, canine, mouse/rat and chicken.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.