Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor™ Plus 594]

• Clone: 352213
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human Carnosine Dipeptidase 1/CNDP1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carnosine Dipeptidase 1/CNDP1 Antibody (352213) [Alexa Fluor™ Plus 594]

• beta-Ala-His dipeptidase
• Carnosinase 1
• carnosine dipeptidase 1 (metallopeptidase M20 family)
• Carnosine Dipeptidase 1
• CN1MGC102737
• CNDP dipeptidase 1
• CNDP1
• CPGL2
• CPGL2MGC142072
• EC 3.4.13.20
• Glutamate carboxypeptidase-like protein 2
• HsT2308
• MGC10825
• Serum carnosinase

Background

The human CNDP1 gene encodes carnosine dipeptidase 1, a member of the M20 family of metalloproteases (1, 2). Also known as X-His dipeptidase, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), CNDP1 is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa = beta -Ala (carnosine) and Xaa = gamma -aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter fucntions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase. CNDP1 consists of a signal peptide (residues 1 to 26) and the mature chain (residues 27 to 507). The amino acid sequence of human CNDP1 is 97%, 85%, 82% and 67% identical to that of chimpanzee, canine, mouse/rat and chicken.

1. Teufel, M. et al. (2004) J. Biol. Chem. 278:6521.
2. Bauer, K. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) p. 1022, Academic Press, San Diego.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.