Calsyntenin-1 Antibody

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Western blot shows lysates of human brain cortex and brain cerebellum tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Calsyntenin‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5346) ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

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Calsyntenin-1 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Calsyntenin-1 isoform 2
Arg30-Thr851
Accession # AAH33902
Specificity
Detects human Calsyntenin-1 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Calsyntenin-2 and rhCalsyntenin-3 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
CLSTN1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Calsyntenin-1 Antibody

  • alcadein alpha 1
  • Alcadein-alpha
  • ALC-ALPHA
  • alcalpha1
  • alcalpha2
  • Alzheimer-related cadherin-like protein
  • cadherin-related family member 12
  • calsyntenin 1
  • Calsyntenin1
  • Calsyntenin-1
  • CDHR12
  • CLSTN1
  • CS1
  • CSTN1
  • FLJ32258
  • KIAA0911alcadein-alpha
  • Non-classical cadherin XB31alpha
  • non-classical cadherin XB31alpha1
  • PIK3CD
  • XB31alpha

Background

Calsyntenin-1 (CST-1; also Alcadein-alpha ) is a 140‑150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of almost all neurons. It is a calcium-binding protein that may regulate post-synaptic signaling and APP cleavage and gene activation. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes APP AICD gene activation. Mature human CST-1 is a 953 amino acid (aa) type I transmembrane protein. It contains two cadherin domains (aa 38‑265) in its extracellular region (aa 29‑859) and a 101 aa cytoplasmic tail. Extracellular cleavage occurs at Met825 Ala826, generating a soluble 115 kDa ECD. Isoforms involve a 78 aa substitution for aa 917‑981, plus deletions of aa 72‑81 and 507‑525. Over aa 30‑851, human CST-1 shares 92% aa identity with mouse CST-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CLSTN1
Entrez
Uniprot