Cannabinoid R2/CB2/CNR2 Antibody

Western Blot: Cannabinoid R2/CB2/CNR2 Antibody [NB300-606] - Analysis of 25 ug of PC-3 (lane 1) and Jurkat (lane 2) cell lysates.

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

Cannabinoid R2/CB2/CNR2 Antibody Summary

• Immunogen: A fusion protein containing the first 33 amino acid residues from human CB2.
• Specificity: Cannabinoid Receptor 2
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CNR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:50
  • Immunocytochemistry/ Immunofluorescence 1:100
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Frozen 1:100
  • Immunohistochemistry-Paraffin 1:100
  • Western Blot 1:250 - 1:2500
• Application Notes: WB: Detects an approx. 60 kDa protein representing CB2 from human spinal cord homogenate.
• Control:

  Cannabinoid R2/CB2/CNR2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA and 30% glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cannabinoid R2/CB2/CNR2 Antibody

• Cannabinoid R2
• cannabinoid receptor 2 (macrophage)
• CannabinoidR2
• CB-2
• CB2cannabinoid receptor 2
• CB2R
• CNR2
• CX5
• CX5testis-dominant CNR2 isoform CB2
• hCB2

Background

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cannabinoid R2/CB2/CNR2 Antibody (NB300-606)(2)

Publications using NB300-606

• Saito H, Yokoyama T, Nakamuta N, Yamamoto Y. Immunohistochemical distribution of cannabinoid receptor type 1 (CB1) and type 2 (CB2) in the rat carotid body. Acta histochemica 2024-10-13 [PMID: 39405990]
• Patsenker E, Stoll M, Millonig G et al. Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis. Mol Med. 2011-08-19 [PMID: 21863215]

Bioinformatics

• Gene Symbol: CNR2
• Entrez:
  • 1269(Human)