CAMP/Cathelicidin Antibody

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Immunocytochemistry/ Immunofluorescence: CAMP/Cathelicidin Antibody [NB100-98689] - AKB-4924 pretreatment enhances production of nitric oxide and host defense peptides during UPEC infection. Representative images ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, DB, ICC/IF, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

CAMP/Cathelicidin Antibody Summary

Immunogen
A synthetic peptide from mouse Cathelin related antimicrobial peptide (Cathelicidin, CAMP, CRAMP) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity
Specific for Cathelin related antimicrobial peptide.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CAMP
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Dot Blot
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:100-1:2000
  • Western Blot 1:100-1:2000
Application Notes
Use in IHC-Frozen reported in scientific literature (PMID: 25927232). Use in ICC/IF reported in scientific literature (PMID: 23223145). Use in dot blot reported in scientific literature (PMID: 32321824).
Publications
Read Publications using
NB100-98689 in the following applications:

  • DB
    1 publication
  • 2 publications
  • IHC
    3 publications
  • 1 publication
  • WB
    1 publication

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:33734592).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for CAMP/Cathelicidin Antibody

  • 18 kDa cationic antimicrobial protein
  • Antibacterial peptide FALL-39
  • CAP18
  • CAP-18
  • cathelicidin antimicrobial peptide
  • CRAMP
  • epididymis secretory sperm binding protein
  • FALL-39 peptide antibiotic
  • FALL39
  • FALL-39
  • hCAP-181
  • HSD26
  • LL37

Background

Cathelicidins are a family of antimicrobial proteins predominantly found in the peroxidase negative granules of neutrophils. The cathelicidins are synthesized as preproproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The active biologic domains of the cathelicidins generally reside in the C terminus. The C terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophil granules. FUNCTION: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in bone marrow and testis and neutrophils.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CAMP/Cathelicidin Antibody (NB100-98689)(7)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: DB, ICC/IF, IHC, IHC-Fr, WB.


Filter By Application
DB
(1)
ICC/IF
(2)
IHC
(3)
IHC-Fr
(1)
WB
(1)
All Applications
Filter By Species
Human
(2)
Mouse
(4)
All Species
Showing Publications 1 - 7 of 7.
Publications using NB100-98689 Applications Species
Deng Z, Chen M, Liu Y et al. A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea EMBO molecular medicine Mar 18 2021 [PMID: 33734592] (ICC/IF, Mouse) ICC/IF Mouse
Patras KA, Coady A, Babu P et al. Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection mSphere Apr 22 2020 [PMID: 32321824] (DB, Human) DB Human
Chen S, Ge L, Wang H et al. Eluted 25-hydroxyvitamin D3 from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice Acta Biomater Aug 3 2019 [PMID: 31386930] (IHC, Mouse) IHC Mouse
Bitschar K, Sauer B, Focken J, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors Nat Commun 2019 Jun 21 [PMID: 31227691] (IHC, Human) IHC Human
Lin AE, Beasley FC, Olson J et al. Role of Hypoxia Inducible Factor-1alpha (HIF-1alpha) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr 01 [PMID: 25927232] (IHC-Fr, WB, Mouse) IHC-Fr, WB Mouse
McGee HM, Schmidt BA, Booth CJ et al. IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin J Invest Dermatol 2012 Dec 6 [PMID: 23223145] (IHC, ICC/IF, Mouse) IHC, ICC/IF Mouse
Kang U-B, Yeom J, Kim H-J et al. Expression profiling of more than 3,500 proteins of MSS-type colorectal cancer by stable isotope labeling and mass spectrometry. Journal of Proteomics. 2011 Nov 25. [PMID: 22275073]

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CAMP/Cathelicidin Antibody (NB100-98689). (Showing 1 - 2 of 2 FAQs).

  1. What is the molecular weight of NB100-98689?
    • It was raised against a synthetic peptide derived from the C-terminus of mouse Cathelicidin antimicrobial peptide (CAMP) conjugated to an immunogenic carrier protein. The Uniprot listing for murine CAMP gives a theoretical molecular weight of 19.6kDa: Uniprot site As you can see, the full length protein includes a signal peptide and a propeptide.
  2. What is the immunogen range for this product?
    • The immunogen falls between amino acids 140-173 of the mouse protein

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CAMP
Entrez
Uniprot