Cadherin-17 Antibody (CDH17/8158R])

Formalin-fixed, paraffin-embedded human colon stained with Cadherin-17 antibody (CDH17/8158R]). Inset: PBS instead of primary antibody; secondary only negative control.

• Reactivity: Hu
• Applications: IHC
• Clone: CDH17/8158R]
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

Cadherin-17 Antibody (CDH17/8158R]) Summary

• Description: Store at 2 to 8C. Non-hazardous. No MSDS required.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant fragment (around aa 242-418) of human Cadherin-17 protein (CDH17) (exact sequence is proprietary)
• Localization: Cell Surface. Cytoplasm.
• Marker: Liver-Intestine Marker
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: CDH17
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin 1-2ug/ml
• Application Notes: Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10mM PBS with 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein A purified

Alternate Names for Cadherin-17 Antibody (CDH17/8158R])

• cadherin 17, LI cadherin (liver-intestine)
• cadherin
• cadherin-16
• Cadherin17
• Cadherin-17
• CDH16
• CDH17
• FLJ26931
• HPT-1 cadherin
• HPT1
• HPT-1
• human intestinal peptide-associated transporter HPT-1
• human peptide transporter 1
• Intestinal peptide-associated transporter HPT-1
• LI cadherin
• LI-cadherin
• Liver-intestine cadherin
• MGC138218
• MGC142024

Background

LI Cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDH17