C1qTNF3/CORS26/CTRP3 Antibody [Unconjugated]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

C1qTNF3/CORS26/CTRP3 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse CTRP3/C1qTNF3/CORS26
  Gln23-Lys246, predicted
  Accession # Q9ES30
• Specificity: Detects mouse CTRP3/C1qTNF3/CORS26 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately
  5% cross‑reactivity with recombinant human CTRP3/C1qTNF3/CORS26 is observed and less than 2% cross‑reactivity with recombinant mouse Acrp30 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: C1QTNF3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for C1qTNF3/CORS26/CTRP3 Antibody [Unconjugated]

• C1ATNF3
• C1q and tumor necrosis factor related protein 3
• C1qTNF3
• Cartducin
• cartonectin
• collagenous repeat-containing sequence of 26-kDa
• complement C1q tumor necrosis factor-related protein 3
• complement-c1q tumor necrosis factor-related protein 3
• Corcs
• Cors
• CORS26
• Cors-26
• CTRP3
• CTRP32310005P21Rik
• FLJ37576
• Secretory protein CORS26

Background

CORS26, also known as C1qTNF3, belongs to the highly conserved family of Acrp30/Adiponectin paralogs known as C1q andTNF-related protein family. All family members share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. Human and mouse CORS26 share approximately 95% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for C1qTNF3/CORS26/CTRP3 Antibody (AF2436)(6)

Publications using AF2436

• KL Thomas, CL Root, JM Peterson Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice PLoS ONE, 2022-01-07;17(1):e0258557. 2022-01-07 [PMID: 34995284] (Western Blot, Mouse)
• Ashley R. DeGroat, Christina K. Fleming, Samantha M. Dunlay, Kendra L. Hagood, Jonathan P. Moorman, Jonathan M. Peterson The sex specific effect of alcohol consumption on circulating levels of CTRP3 PLOS ONE 2018-11-07 [PMID: 30403751]
• Megan R. Kwon, Eileen Cress, W. Andrew Clark, Arsham Alamian, Yongke Lu, Jonathan M. Peterson The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers PeerJ 2018-03-05 [PMID: 29527418]
• Otani M, Kogo M, Furukawa S, Wakisaka S, Maeda T The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway. Cytokine, 2012-02-17;58(2):238-44. 2012-02-17 [PMID: 22342437] (IHC-P, Western Blot, Mouse)
• Peterson JM, Wei Z, Wong GW C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J. Biol. Chem., 2010-10-15;285(51):39691-701. 2010-10-15 [PMID: 20952387] (Western Blot, Mouse)
• Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Revett T, Gimeno R, Lodish HF Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem. J., 2008-12-01;416(2):161-77. 2008-12-01 [PMID: 18783346] (Western Blot, Human)

Bioinformatics

• Gene Symbol: C1QTNF3
• Uniprot:
  • Q9ES30()