BMP-2/BMP-7 Heterodimer Antibody (369505)

• Reactivity: Hu
• Applications: WB
• Clone: 369505
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

BMP-2/BMP-7 Heterodimer Antibody (369505) Summary

• Immunogen: E. coli-derived recombinant human BMP‑2/BMP‑7 Heterodimer
  Ala284-Arg396 (BMP-2), Ser293-His431 (BMP-7)
  Accession # NP_001191, NP_001710
• Specificity: Detects human BMP‑2/BMP‑7 Heterodimer in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross‑reactivity with recombinant human (rh) BMP-2 is observed, and no cross-reactivity with rhBMP-4/7, -4, -5, -6, -7, or -8 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: BMP2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMP-2/BMP-7 Heterodimer Antibody (369505)

• BDA2;BMP2A;Bone morphogenetic protein 2;SSFSC;SSFSC1
• BMP-2/BMP-7 Heterodimer

Background

Bone Morphgenetic Protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), and BMP-2 are members of the BMP subgroup of the TGF-beta superfamily and signal through heterodimeric complexes composed of type I and type II BMP receptors. After proteolytic removal of their propeptides, BMP-2 and BMP-7 can associate into 38 kDa disulfide-linked heterodimers. The heterodimers are significantly more potent than either homodimer in osteoblast differentiation and bone formation assays. Human and mouse BMP-2 and BMP-7 share 100% and 98% aa sequence identity, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BMP2
• Uniprot:
  • NP_001191, NP_001710()