Vang-like Protein 2/VANGL2 Antibody

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Western blot shows lysates of mouse kidney, human and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/Rat Vang-like Protein 2/VANGL2 Antigen Affinity-purified Polyclonal Antibody ...read more
Vang-like Protein 2/VANGL2 was detected in immersion fixed frozen sections of mouse embryo (E15.5) using Sheep Anti-Human/Mouse/Rat Vang-like Protein 2/VANGL2 Antigen Affinity-purified Polyclonal Antibody (Catalog # ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Vang-like Protein 2/VANGL2 Antibody Summary

Immunogen
E. coli-derived recombinant human Vang-like Protein 2/VANGL2
Gln241-Val521
Accession # Q9ULK5
Specificity
Detects human, mouse, and rat Vang-like Protein 2/VANGL2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human VANGL1 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
VANGL2
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Publications
Read Publications using
AF4815 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Vang-like Protein 2/VANGL2 Antibody

  • KIAA1215Loop-tail protein 1 homolog
  • loop-tail-associated protein
  • LPP1
  • LTAP
  • LTAPVan Gogh-like protein 2
  • MGC119403
  • MGC119404
  • STB1
  • STB1Strabismus 1
  • STBM
  • STBM1
  • Strabismus
  • vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)
  • Vang like Protein 2
  • VANGL2
  • vang-like 2 (van gogh, Drosophila)
  • Vang-like Protein 2

Background

VANGL2 (van Gogh-like protein 2; also Strabismus and Ltap) is a 65 kDa member of the Vang family of proteins. It is found in the membranes of embryonic neurons and epithelium where it associates with DVL1-3 and various frizzleds. VANGL2 mutations are associated with neural tube defects. Human VANGL2 is a 521 amino acid (aa) 4-transmembrane protein that contains an N-terminal (aa 1‑108) and C-terminal (aa 239‑521) cytoplasmic domain. There is a Ser-rich region in the N-terminus (aa 5‑20) and a PDZ-binding motif over aa 506‑521. Over aa 241‑521, human, mouse and rat show total identity in amino acid sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Vang-like Protein 2/VANGL2 Antibody (AF4815)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, Immunoprecipitation, Western Blot.


Filter By Application
ICC
(1)
IHC
(1)
IHC-Fr
(1)
Immunoprecipitation
(1)
Western Blot
(3)
All Applications
Filter By Species
Human
(3)
Mouse
(2)
Rat
(2)
All Species
Showing Publications 1 - 7 of 7.
Publications using AF4815 Applications Species
X Cheng, L Song, M Lan, B Shi, J Li Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential Exp Ther Med, 2018;15(1):247-253. 2018 [PMID: 29375687] (Western Blot, Rat) Western Blot Rat
Cheng X, Song L, Lan M, Shi B, Li J Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Exp Ther Med, 0;15(1):247-253. 0 [PMID: 29375687] (Western Blot, Rat) Western Blot Rat
W Luo, H Yi, J Taylor, JD Li, F Chi, NW Todd, X Lin, D Ren, P Chen Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity Sci Rep, 2017;7(0):45870. 2017 [PMID: 28358397] (IHC, Mouse) IHC Mouse
C Dyberg, P Papachrist, BH Haug, H Lagercrant, P Kogner, T Ringstedt, M Wickström, JI Johnsen Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma BMC Cancer, 2016;16(1):259. 2016 [PMID: 27036398] (Western Blot, Human) Western Blot Human
VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. J. Cell. Sci., 2012;125(0):2141-7. 2012 [PMID: 22357946] (ICC, Human) ICC Human
Trichas G, Joyce B, Crompton LA, Wilkins V, Clements M, Tada M, Rodriguez TA, Srinivas S Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm. PLoS Biol., 2011;9(2):e1001019. 2011 [PMID: 21364967] (IHC-Fr, Mouse) IHC-Fr Mouse
Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T Vang-like protein 2 and Rac1 interact to regulate adherens junctions. J. Cell. Sci., 2010;123(0):472-83. 2010 [PMID: 20067994] (Immunoprecipitation, Human) Immunoprecipitation Human

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Bioinformatics

Gene Symbol VANGL2
Uniprot