beta-Catenin [p Ser33, p Ser37] Antibody

Images

 
Western Blot: beta Catenin [p Ser33, p Ser37] Antibody [NB300-272] - Human embryonic kidney cell (HEK) lysate showing immunolabeling with the phospho-specific Ser33,37 B-catenin antibody, NB300-272 (upper panel) and a ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB300-272
    • Availability
      Product Discontinued

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beta-Catenin [p Ser33, p Ser37] Antibody Summary

Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH
Modification
p Ser33, p Ser37
Localization
Cytoplasmic (high level of ser/thr phosphorylation) or bound to CDH1. Translocates to the nucleus (low level of ser/thr phosphorylation).
Marker
Epithelial Cell Marker, Adherens Junction Marker
Specificity
Specific for the ~83k beta-catenin phosphorylated at Ser33 and Ser37.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CTNNB1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Positive Control
beta-Catenin Lysate (NBL1-09577)
Publications
Read Publications using NB300-272.

Reactivity Notes

Reactivity assumed based on 100% sequence identity: Mouse, Rat and Xenopus.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for beta-Catenin [p Ser33, p Ser37] Antibody

  • bCatenin
  • beta 1 (88kD)
  • beta-Catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin beta-1
  • CTNNB
  • CTNNB1
  • DKFZp686D02253
  • FLJ25606
  • FLJ37923

Background

B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of B-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3B (GSK3B) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of B-catenin. Mutations in components of this phosphorylation regulated process that prevent B-catenin hyperphosphorylation by GSK3B are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for beta-Catenin Antibody (NB300-272)(4)

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CTNNB1
Entrez
Uniprot