Bcl-xL Antibody

Product Discontinued

Bcl-xL Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 20-150 of Human Bcl-Xl.
• Localization: Cell Membrane, Cytoplasmic and Nuclear membrane
• Specificity: Bcl-Xl
• Clonality: Polyclonal
• Host: Chicken
• Gene: BCL2L1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Application Notes: WB: 1/500. Predicted molecular weight: 28 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
• Control:

  Bcl-xL Overexpression Lysate

Reactivity Notes

Cross-reacts with Human, mouse, and rat. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for Bcl-xL Antibody

• Apoptosis regulator Bcl-X
• bcl2-L-1
• BCL2-like 1
• bcl-2-like protein 1
• BCLXBCL2LBcl-X
• BclxL
• Bcl-xL
• BCL-XL/S
• BCLXS
• bcl-xS
• DKFZp781P2092

Background

The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCL2L1
• Entrez:
  • 598(Human)
  • 12048(Mouse)
  • 24888(Rat)