Bcl-xL Products

Antibodies
Bcl-xL Antibody (2052A) [Unco ...
Bcl-xL Antibody (2052A) [Unconjuga...
MAB894
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Rabbit Monoclonal
Bcl-xL Antibody
Bcl-xL Antibody
NB100-56104
Species: Hu, Mu, Rt, Bovine, Sheep, Gerbil
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
Bcl-xL Antibody
Bcl-xL Antibody
NB100-56105
Species: Hu, Mu, Rt, Ca, Ge
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
Bcl-xL Overexpression Lysate ...
Bcl-xL Overexpression Lysate (Dena...
H00000598-T01
Species: Hu
Applications: WB
Bcl-xL Overexpression Lysate ...
Bcl-xL Overexpression Lysate (Native)
NBP2-08227
Applications: WB
Bcl-xL Overexpression Lysate ...
Bcl-xL Overexpression Lysate (Native)
NBL1-07946
Applications: WB
Proteins
Human Bcl-xL Protein
Human Bcl-xL Protein
NBP2-34899
Species: Hu
Applications: Func, PAGE
Mouse Bcl-xL Protein
Mouse Bcl-xL Protein
NBP2-35141
Species: Mu
Applications: Func, PAGE
Bcl-xL Recombinant Protein
Bcl-xL Recombinant Protein
H00000598-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Bcl-xL RNAi
Bcl-xL RNAi
H00000598-R02
Species: Hu
Bcl-xL RNAi
Bcl-xL RNAi
H00000598-R01
Species: Hu

Description

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 598
Alternate Names
  • BCL-XL/S
  • Bcl2-L-1
  • BCLXS
  • bcl2-L-1
  • BCLXL
  • bcl-2-like protein 1
  • Apoptosis regulator Bcl-X
  • bcl-xS
  • bcl-xL
  • BCLXBCL2LBcl-X
  • DKFZp781P2092
  • BCL2-like 1

Research Areas for Bcl-xL

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for Bcl-xL

Discover related pathways, diseases and genes to Bcl-xL. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Bcl-xL Blog Posts

Check out the latest blog posts on Bcl-xL.
BAG3 - Hsp70 is my friend!
The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.
Read more Bcl-xL related blogs.