Bcl-xL Products

Description

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

Bioinformatics

Entrez	12048 Mouse 24888 Rat 598 Human
Uniprot	AAH19307 Human CAA80661 Human NM_138578 Human NP_001182 Human NP_612815 Human NP_612815.1 Human Q07817 Human
Product By Gene ID	598
Alternate Names	Apoptosis regulator Bcl-X Bcl2-L-1 bcl2-L-1 BCL2-like 1 bcl-2-like protein 1 BCLXBCL2LBcl-X BCLXL bcl-xL BCL-XL/S BCLXS bcl-xS DKFZp781P2092

Research Areas for Bcl-xL

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

Related Bcl-xL Blog Posts

Check out the latest blog posts on Bcl-xL.

BAG3 - Hsp70 is my friend! The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.

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