Reactivity | HuSpecies Glossary |
Applications | WB, IHC, IP |
Clonality | Polyclonal |
Host | Goat |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human ARSA Arg19-Ala507 Accession # AAH14210 |
Specificity | Detects human ARSA in direct ELISAs and Western blots. In direct ELISAs, less than 30% cross-reactivity with recombinant mouse ARSA is observed. |
Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Goat |
Gene | ARSA |
Purity Statement | Antigen Affinity-purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Publications |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms (2). The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507) (3). Recombinant human ARSA corresponds to the mature chain and has sulfatase activity described above.
Secondary Antibodies |
Isotype Controls |
Diseases for Arylsulfatase A/ARSA Antibody (AF2485)Discover more about diseases related to Arylsulfatase A/ARSA Antibody (AF2485).
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PTMs for Arylsulfatase A/ARSA Antibody (AF2485)Learn more about PTMs related to Arylsulfatase A/ARSA Antibody (AF2485).
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