Artemin Antibody (314908)


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Product Details

Reactivity HuSpecies Glossary
Applications WB

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Artemin Antibody (314908) Summary

E. coli-derived recombinant human Artemin
Accession # Q5T4W7.1
Detects human Artemin in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) BIG-H3, rhCripto-1, recombinant mouse (rm) Cripto-1, recombinant Drosophila DPP, rhDPP-6, rhGDNF, rhLAP, rhLatent TGF-beta 1, rhTGF-beta 1.2, rhTGF‑ beta 3, rhLefty, rmLefty-1, rhMIS, rhNeurturin, rmNODAL, rhPersephin, recombinant amphibian TGF-beta 5, rhTGF-alpha or rhTGF-beta 2 is observed.
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 ug/mL
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MAB2589 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Artemin Antibody (314908)

  • Artemin
  • ARTN
  • Enovin
  • EVN
  • EVNneurotrophic factor
  • NBN
  • Neublastin


Human Artemin (ARTN; also known as enovin and neublastin) is a GDNF family ligand that is distantly related to the TGF-beta superfamily of molecules (1‑4). As such, it is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment (5‑7). Alternate splicing and start sites create signal sequences of 22, 30 and 39 aa, respectively. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-beta signature cysteine-knot motif (5, 7). In the mature region, human ARTN is 89% and 88% aa identical to rat (8) and mouse ARTN (5, 7), respectively. Cells known to express ARTN include Schwann cells (2) and embryonic vascular smooth muscle cells (9). Human ARTN is active on rodent cells (5). The receptor for ARTN has been identified as the ligand binding subunit GFR alpha -3 plus the signal transducing subunit, RET (1, 5). The GFR alpha -1/RET receptor complex has also been suggested to be a ligand binding unit for ARTN (2, 5). Evidence, however, suggests that the GFR alpha -1/RET complex plays no functional role in ARTN activity (10, 11). ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system (9). It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system (5). Finally, it has been reported to reverse neuropathic pain due to nerve injury, and to help resolve morphological changes associated with nerve damage (12).

  1. Airaksinen, M.S. and M. Saarma (2002) Nat. Rev. Neurosci. 3:383. 
  2. Saarma, M. (2000) Eur. J. Biochem. 267:6968. 
  3. Sariola, H. et al. (2003) J. Cell Sci. 116:3855. 
  4. Chang, H. et al. (2002) Endocr. Rev. 23:787. 
  5. Baloh, R.H. et al. (1998) Neuron 21:1291. 
  6. Masure, S. et al. (1999) Eur. J. Biochem. 266:892. 
  7. Rosenblad, C. et al. (2000) Mol. Cell. Neurosci. 15:199.
  8. Stover, T. et al. (2000) Brain Res. Mol. Brain Res. 76:25.
  9. Honma, Y. et al. (2002) Neuron 35:267.
  10. Rakowicz, W.P. et al. (2002) J. Neurosci. 22:3953.
  11. Carmillo, P. et al. (2005) Biochemistry 44:2545.
  12. Gardell, L.R. et al. (2003) Nat. Med. 9:1383.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Artemin Antibody (MAB2589)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Immunodepletion.

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Gene Symbol ARTN