APPL Antibody (OTI4B11) [mFluor Violet 450 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: OTI4B11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 450 SE

APPL Antibody (OTI4B11) [mFluor Violet 450 SE] Summary

• Immunogen: Full length human recombinant protein of human APPL1 (NP_036228) produced in HEK293T cell.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: APPL1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for APPL Antibody (OTI4B11) [mFluor Violet 450 SE]

• Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
• adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
• adaptor protein, phosphotyrosine interaction, PH domain and leucine zippercontaining 1
• AKT2 interactor
• APPL
• APPL1
• APPLdip13-alpha
• DCC-interacting protein 13-alpha
• DIP 13 alpha
• DIP13A
• DIP13alpha
• Dip13-alpha
• KIAA1428
• signaling adaptor protein DIP13alpha

Background

APPL is encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APPL1