Apelin Antibody

Product Discontinued

Apelin Antibody Summary

• Immunogen: Synthetic peptide derived from C terminal region of human Apelin
• Specificity: Reacts specifically with 8,5 kDa of human APLN protein
• Clonality: Polyclonal
• Host: Rabbit
• Gene: APLN
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100 to 1:500
  • Western Blot 1:500 to 1:2000

Reactivity Notes

Human, Mouse, Rat and Bovine.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Antiserum
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.2 ml distilled water.

Alternate Names for Apelin Antibody

• AGTRL1 ligand
• AGTRL1 Lligand
• APEL
• Apelin
• apelin, AGTRL1 ligand
• APJ endogenous ligand
• APLN
• XNPEP2

Background

Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Apelin Antibody (NBP1-07130)(2)

Publications using NBP1-07130

• Sekerci R, Acar N, Tepekoy F, Ustunel I. Apelin/APJ expression in the heart and kidneys of hypertensive rats. Acta Histochem. 2018-01-29 [PMID: 29395316] (IF/IHC, Rat)
• Kilinc L, Avci S, Soylu H Et al. Effect of Ozone on Apelin and APJ Expressions in Rat Peritonitis-Constituted With Colon Anastomosis Research Square 2021-08-23 (IHC-P, WB, Rat)

Bioinformatics

• Gene Symbol: APLN
• Entrez:
  • 8862(Human)
  • 30878(Mouse)
  • 58812(Rat)
• Uniprot:
  • Q9ULZ1(Human)