Annexin A3 Antibody (693510) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 693510
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Annexin A3 Antibody (693510) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Annexin A3
  Ala2-Asp323
  Accession # P12429
• Specificity: Detects human Annexin A3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Annexin A1, A2, A4, A6, A8, A9, A10, A11, or A13 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Annexin A3 Antibody (693510) [Alexa Fluor® 350]

• 35-alpha calcimedin
• Annexin A3
• annexin A3,1,2-cyclic-inositol-phosphate phosphodiesterase
• Annexin III
• annexin-3
• ANXA3
• Calcimedin 35-alpha
• calcimedin 35-alpha
• Lipocortin III
• PAP-III
• Placental anticoagulant protein III
• placental anticoagulant protein III, calcimedin 35-alpha

Background

Annexin A3 (ANXA3), also known as Annexin III and Lipocortin III (LPC3), is a 36 kDa member of the Annexin family of calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing calcium-dependent phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 amino acid (aa) annexin repeats. Annexin A3 is upregulated in microglia following stroke and in parenchymal hepatocytes in regenerating liver. It can be up- or down‑regulated in various carcinomas. Alternate splicing generates an additional isoform with a 30 amino acid (aa) deletion near the N-terminus. Human Annexin A3 shares 89% and 85% aa sequence identity with mouse and rat Annexin A3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.