Human Androgen R/NR3C4 ELISA Kit (Chemiluminescence)

ELISA: Human Androgen R/NR3C4 ELISA Kit (Chemiluminescence) [NBP2-69854] - Samples were spiked with high concentrations of Human Androgen R/NR3C4 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

ELISA: Human Androgen R/NR3C4 ELISA Kit (Chemiluminescence) [NBP2-69854] - Standard Curve Reference

• Reactivity: Hu
• Applications: ELISA
• Suitable Sample Type: Serum, plasma and other biological fluids
• Standard Curve Range: 78.13-5000 pg/mL
• Sensitivity: 46.88 pg/mL

Human Androgen R/NR3C4 ELISA Kit (Chemiluminescence) Summary

• Specificity: This kit recognizes Human AR in samples. No significant cross-reactivity or interference between Human AR and analogues was observed.
• Standard Curve Range: 78.13-5000 pg/mL
• Sensitivity: 46.88 pg/mL
• Assay Type: Sandwich-CLIA
• Inter-Assay: CV% < 9.22%
• Intra-Assay: CV% < 11.21%
• Spike Recovery: 85-117%
• Sample Volume: 100 uL
• Kit Type: ELISA Kit (Chemiluminescence)
• Gene: AR

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Human Androgen R/NR3C4 ELISA Kit (Chemiluminescence)

• AIS
• Androgen R
• androgen receptor
• AndrogenR
• AR
• DHTR
• DHTRTFM
• Dihydrotestosterone receptorHYSP1
• HUMARA
• NR3C4
• NR3C4KD
• Nuclear receptor subfamily 3 group C member 4
• SBMA
• SMAX1
• SMAX1SBMA
• spinal and bulbar muscular atrophy

Background

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: AR