Androgen R/NR3C4 Antibody (636005) [Alexa Fluor® 700]

• Applications: IHC
• Clone: 636005
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Androgen R/NR3C4 Antibody (636005) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Androgen R/NR3C4
  Thr660-Gln919
  Accession # P10275
• Specificity: Detects human Androgen R/NR3C4 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

The Androgen Receptor (AR) is a 90 kDa steroid hormone receptor that is critical for the development and function of the male reproductive system. AR binding to testosterone or 5 alpha -dihydrotestosterone (DHT) triggers receptor dimerization followed by translocation to the nucleus where it promotes transcription of androgen responsive genes. Multiple polymorphisms in AR are linked to the development of prostate cancer. The ligand binding domain of human AR (aa 661-920) shares 100% aa sequence identity with mouse and rat AR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.