Aminopeptidase P2/XPNPEP2 Antibody (391118)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 391118
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Aminopeptidase P2/XPNPEP2 Antibody (391118) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Aminopeptidase P2/XPNPEP2
  His22-Ala650
  Accession # AAB96394
• Specificity: Detects human Aminopeptidase P2/XPNPEP2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 25% cross‑reactivity with recombinant mouse Aminopeptidase P2/XPNPEP2 and no cross‑reactivity with recombinant human XPNPEP1 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: XPNPEP2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

The purchase of this product conveys to the buyer the limited, non-exclusive, non-transferable right (without the right to resell, repackage, or further sublicense) to use these reagents for non-commercial research purposes only. No other license is granted to the buyer whether expressly, by implication, by estoppel or otherwise. In particular, the purchase of this product does not include nor carry any right or license to use, develop, or otherwise exploit this product commercially, which includes without limitation, provision of services to a third party, generation of commercial databases, clinical diagnostics or therapeutics, or drug development. This Product is manufactured under a license to U.S. Patent Nos. 6,399,349 and 7,273,718. Any party desiring rights under this patent should contact Ryogen LLC, Montebello Park, 75 Montebello Road, Suffern, NY 10901.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Aminopeptidase P2/XPNPEP2 Antibody (391118)

• Aminoacylproline aminopeptidase
• Aminopeptidase P2
• APP2
• EC 3.4.11.9
• mAmP
• Membrane-bound aminopeptidase P
• Membrane-bound AmP
• Membrane-bound APP
• xaa-Pro aminopeptidase 2
• XPNPEP2
• X-Pro aminopeptidase 2
• X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

Background

The human XPNPEP2 gene encodes Aminopeptidase P2 (APP2), which is also known as X-prolyl Aminopeptidase 2 or membrane bound Aminopeptidase P (1‑4). It is a member of the M24 family of metalloproteases, which also contains methionine Aminopeptidases, X-Pro dipeptidase, Aminopeptidase P1, Aminopeptidase P homolog, proliferation-associated protein 1, and suppressor of Ty homolog or chromatin-specific transcription elongation factor large subunit (5). Mammalian APP2 are predicted to be GPI-anchored membrane proteases and their biological functions have been reviewed (6). Human APP2 is widely expressed in many adult tissues with the highest levels in the kidney (7).

1. Venema, R.C. et al. (1997) Biochim. Biophys. Acta 1354:45.
2. Sprinkle, T.J. et al. (1998) Genomics 50:114.
3. Cottrell, G.S. et al. (1998) Biochem. Soc. Trans. 26:S248.
4. Prueitt, R.L. et al. (2000) Cytogenet. Cell Genet. 89:44.
5. Barrett, A.J. et al. (2004) Handbook of Proteolytic Enzymes, Elsevier Academic Press, San Diego.
6. Simmons, W.H. (2004) in Handbook of Proteolytic Enzymes (Barrett, A.J. et al. eds.) p. 934, Elsevier Academic Press, San Diego.
7. Ersahin C. et al. (2005) Arch. Biochem. Biophys. 435:303.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: XPNPEP2
• Uniprot:
  • AAB96394()