alpha-Actinin 1 Antibody (CB11)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-Fr
Clone
CB11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

alpha-Actinin 1 Antibody (CB11) Summary

Immunogen
The antibody reacts with the alpha-Actinin antigen.
Marker
Z-disk Marker
Specificity
The antibody is specific to the 100 kD a-actinin polypeptide and reacts with human and chicken cells. Monoclonal antibody to a-actinin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Purified a-actinin from chicken gizzard was used as an immunogen.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ACTN1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
Immunohistochemical stainings on frozen sections, western blotting and other immunoassays for cellular and tumor biology.Working dilution in western blotting is at least 1:1000.

Reactivity Notes

May react with Chicken.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS solution containing 1.0% w/v BSA
Preservative
0.1% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for alpha-Actinin 1 Antibody (CB11)

  • actinin 1 smooth muscle
  • actinin, alpha 1
  • ACTN1
  • alphaActinin 1
  • alpha-Actinin 1
  • Alpha-actinin cytoskeletal isoform
  • alpha-actinin-1
  • BDPLT15
  • F-actin cross-linking protein
  • FLJ40884
  • FLJ54432
  • Non-muscle alpha-actinin-1

Background

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ACTN1
Entrez