Aldo-keto Reductase 1C3/AKR1C3 Antibody

Images

 
Western Blot: Aldo-keto Reductase 1C3/AKR1C3 Antibody [NBP1-33556] - Sample (30 ug of whole cell lysate) A: Hela B: Hep G2 C: Molt-4 10% SDS PAGE; antibody diluted at 1:1000.
Immunohistochemistry-Paraffin: Aldo-keto Reductase 1C3/AKR1C3 Antibody [NBP1-33556] - Paraffin-embedded NCI-N87 xenograft, using antibody at 1:100 dilution.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Aldo-keto Reductase 1C3/AKR1C3 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human AKR1C3. The exact sequence is proprietary.
Localization
Cytoplasm
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AKR1C3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Aldo-keto Reductase 1C3/AKR1C3 Antibody

  • 17-beta-hydroxysteroid dehydrogenase type 5
  • 3-alpha-HSD type 2
  • 3-alpha-hydroxysteroid dehydrogenase type 2
  • AKR1C3
  • Aldo-keto Reductase 1C3
  • aldo-keto reductase family 1 member C3
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
  • AldoketoReductase 1C3
  • Chlordecone reductase homolog HAKRb
  • DD3
  • DD-3
  • DD317-beta-HSD 5
  • DDH1
  • DDX
  • Dihydrodiol dehydrogenase 3
  • Dihydrodiol dehydrogenase type I
  • dihydrodiol dehydrogenase X
  • EC 1.1.1
  • EC 1.1.1.112,3-alpha-HSD type II, brain
  • EC 1.1.1.188
  • EC 1.1.1.213
  • EC 1.1.1.63
  • EC 1.1.1.64
  • EC 1.3.1.20
  • HA1753
  • HAKRB
  • HAKRBtype IIb 3-alpha hydroxysteroid dehydrogenase
  • HAKRe
  • HSD17B5
  • hydroxysteroid (17-beta) dehydrogenase 5
  • Indanol dehydrogenase
  • KIAA0119hluPGFS
  • PGFS
  • Prostaglandin F synthase
  • Testosterone 17-beta-dehydrogenase 5
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AKR1C3
Entrez