AdipoR1 Antibody

Images

 
Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Paraffin section of human muscle
Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Antibody to human AdipoR1 C-terminus on paraffin section of human liver

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

AdipoR1 Antibody Summary

Immunogen
Synthetic peptide (CYAARIPERFFPGKFDIWFQSHQIF) corresponding to aa 317-340 of the C-terminal domain of Human, Mouse and Rat ADPR 1 Receptor
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ADIPOR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Paraffin 1:250
Publications
Read Publications using
NBP1-28640 in the following applications:

  • 2 publications
  • WB
    2 publications

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 1.0 mg/ml BSA
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for AdipoR1 Antibody

  • ACDCR1
  • adiponectin receptor 1
  • adiponectin receptor protein 1
  • AdipoR1
  • ADR1
  • CGI45
  • FLJ42464
  • PAQR1
  • PAQR1FLJ25385
  • Progestin and adipoQ receptor family member I
  • TESBP1A

Background

Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports the conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for AdipoR1 Antibody (NBP1-28640)(6)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IHC-P, WB.


Filter By Application
IHC-P
(2)
WB
(2)
All Applications
Filter By Species
Human
(2)
Rat
(1)
All Species

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ADIPOR1
Entrez