AdipoR1 Antibody

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Paraffin section of human muscle

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Antibody to human AdipoR1 C-terminus on paraffin section of human liver

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC, IHC-P
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 1.0 mg/ml

AdipoR1 Antibody Summary

• Immunogen: Synthetic peptide (CYAARIPERFFPGKFDIWFQSHQIF) corresponding to aa 317-340 of the C-terminal domain of Human, Mouse and Rat ADPR 1 Receptor
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ADIPOR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Paraffin 1:250
• Positive Control:

  AdipoR1 Lysate (NBP2-65858)

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 1.0 mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for AdipoR1 Antibody

• ACDCR1
• adiponectin receptor 1
• adiponectin receptor protein 1
• AdipoR1
• ADR1
• CGI45
• FLJ42464
• PAQR1
• PAQR1FLJ25385
• Progestin and adipoQ receptor family member I
• TESBP1A

Background

Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports the conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AdipoR1 Antibody (NBP1-28640)(6)

Publications using NBP1-28640

• Ma H, You GP, Cui F et al. Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD. Ann Hepatol. 2014 Dec 24 [PMID: 25536648] (WB, IHC-P, Rat)
• Takeuchi S, Wada K, Uozumi Y et al. Adiponectin receptor 1 expression is associated with carotid plaque stability. Neurol India 2013 May-Jun [PMID: 23860143] (IHC-P, Human)
• De Rosa A, Monaco ML, Capasso M et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol 2013 Apr 23 [PMID: 23612446] (WB, Human)
• Daniele A, De Rosa A, Nigro E et al. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. The International Journal of Biochemistry & Cell Biology. 2012 Jan 3. [PMID: 22233975]
• Staiger,H et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes 53 (9), 195-2201. 2004 [PMID: 15331527]
• Yamauchi,T et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 (6941), 762-769. 2003 [PMID: 12802337]

Bioinformatics

• Gene Symbol: ADIPOR1
• Entrez:
  • 51094(Human)
  • 72674(Mouse)
  • 289036(Rat)