ADAM10 Antibody Summary
Antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ADAM10. The immunogen is located within the last 50 amino acids of ADAM10.
Mouse (100%), Rat (100%), Bovine (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 1:1000-1:2000
- ELISA 1:100-1:2000
- Immunocytochemistry/Immunofluorescence 1:10-1:2000
ADAM10 can be used for detection of ADAM10 by western blot at 1:1000 to 1:2000 dilution. An approximately 85 kDa band can be detected, which may represent precursor.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for ADAM10 Antibody
- a disintegrin and metalloprotease domain 10
- a disintegrin and metalloproteinase domain 10
- ADAM 10
- ADAM metallopeptidase domain 10
- CD156c antigen
- disintegrin and metalloproteinase domain-containing protein 10
- EC 3.4.24
- Kuzbanian protein homolog
- MADMEC 22.214.171.124
- Mammalian disintegrin-metalloprotease
Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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