ADAM10 Products

Description

Proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).

Bioinformatics

Entrez	102 Human 11487 Mouse 29650 Rat
Uniprot	NP_001101 Human O14672 Human O35598 Mouse
Product By Gene ID	102
Alternate Names	a disintegrin and metalloprotease domain 10 a disintegrin and metalloproteinase domain 10 AD10 ADAM 10 ADAM metallopeptidase domain 10 CD156c antigen CD156c CDw156 disintegrin and metalloproteinase domain-containing protein 10 EC 3.4.24 HsT18717 kuz KUZ Kuzbanian protein homolog MADMEC 3.4.24.81 Mammalian disintegrin-metalloprotease

Diseases related to ADAM10

Discover more about diseases related to ADAM10.

Alzheimer's Disease
Tissue Adhesions
Malignant Neoplasms
Neoplasms
Inflammation
Neuroblastoma
Cell Invasion
Neoplasm Metastasis
Carcinoma
Malignant Neoplasm Of Breast
Nervousness
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Plaque, Amyloid
Dental Plaque
Neurodegenerative Disorders
Dementia
Tumor Angiogenesis
Atherosclerosis
Senile Plaques

Pathways for ADAM10

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Proteolysis
Pathogenesis
Cell Adhesion
Secretion
Cell Migration
Localization
Cell Growth
Cell Proliferation
Cell-cell Adhesion
Rna Interference
Protein Processing
Angiogenesis
Transport
Secretory Pathway
Neurogenesis
Regeneration
Cell Death
Chemotaxis
Endocytosis
Aging

Research Areas for ADAM10

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Apoptosis
Signal Transduction

PTMs for ADAM10

Learn more about PTMs related to ADAM10.

Cleavage
Phosphorylation
Reduction
Glycosylation
Biotinylation
Deacetylation
Dephosphorylation
Palmitoylation
Gamma-cleavage
Acetylation
Oxidation
Ubiquitination

Bioinformatics Tool for ADAM10

Discover related pathways, diseases and genes to ADAM10. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.