Activin RIB/ALK-4 Antibody (6G11)

Product Discontinued

Activin RIB/ALK-4 Antibody (6G11) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: ACVR1B (AAH00254, 24 a.a. - 126 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVE
• Specificity: ACVR1B - activin A receptor, type IB
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACVR1B
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Activin RIB/ALK-4 Antibody (6G11)

• activin A receptor, type IB
• Activin receptor type IB
• Activin receptor-like kinase 4
• Activin RIB
• ActivinRIB
• ACTRIB
• ACVR1B
• ACVRLK4ACTR-IB
• ALK4
• ALK-4
• ALK4activin A receptor, type II-like kinase 4
• EC 2.7.11
• EC 2.7.11.30
• Serine/threonine-protein kinase receptor R2
• SKR2activin receptor type-1B

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACVR1B
• Entrez:
  • 91(Human)
• OMIM:
  • 601300(Human)
• Uniprot:
  • AAH00254(Human)