Activin RIB/ALK-4 Products

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Bioinformatics

Entrez	91 Human
Uniprot	AAA60556 Human AAH00254 Human AAH00254.1 Human NM_004302 Human NM_020327 Human NM_020328 Human NP_001096 Human NP_004293.1 Human P36896 Human
Product By Gene ID	91
Alternate Names	activin A receptor, type IB Activin receptor type IB Activin receptor-like kinase 4 ActRIB ACTRIB ACVRLK4ACTR-IB ALK-4 ALK4activin A receptor, type II-like kinase 4 EC 2.7.11 EC 2.7.11.30 Serine/threonine-protein kinase receptor R2 SKR2activin receptor type-1B

Research Areas for Activin RIB/ALK-4

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Protein Kinase