Acetyl Coenzyme A Carboxylase Beta Antibody

Product Discontinued

Acetyl Coenzyme A Carboxylase Beta Antibody Summary

• Immunogen: Peptide with sequence C-QLGEPDLSDKDRKD corresponding to internal region according to NP_001084.2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ACACB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Acetyl Coenzyme A Carboxylase Beta Antibody

• ACC2ACC-beta
• ACCBacetyl-CoA carboxylase 2
• acetyl-CoA carboxylase beta
• acetyl-Coenzyme A carboxylase beta
• EC 6.4.1.2
• HACC275

Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Acetyl Coenzyme A Carboxylase Beta Antibody (NB100-59750)(1)

Publication using NB100-59750

• Reznick RM, Zong H, Li J et al. Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis. Cell Metab 2007-02-01 [PMID: 17276357]

Bioinformatics

• Gene Symbol: ACACB
• Entrez:
  • 32(Human)
• Uniprot:
  • NP_001084.2(Human)