ABCE1 Antibody (23GB3605)

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, Mycoplasma
• Clone: 23GB3605
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

ABCE1 Antibody (23GB3605) Summary

• Immunogen: A synthesized peptide derived from human ABCE1 (Uniprot: P61221)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ABCE1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Knockdown Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for ABCE1 Antibody (23GB3605)

• 2'-5'-oligoadenylate-binding protein
• ATP-binding cassette, sub-family E (OABP), member 1
• huHP68
• OABP
• Ribonuclease 4 inhibitor
• ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent) inhibitor
• RLIABC38
• RNase L inhibitor
• RNASEL1
• RNASELIRNS4IATP-binding cassette sub-family E member 1

Background

ATP-binding cassette sub-family E member 1 (ABCE1) is a member of the ATP-binding cassette sub-family E, but is not a membrane transporter.

ABCE-1 interacts with RNASEL to inhibit its endoribonuclease activity, and antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. ABCE1 is activated by encephalomyocarditis virus (EMCV) and HIV-1, and recently it has been found to be essential for the assembly of immature immunodeficiency virus capsids.

ABCE1 antibodies are useful tools for HIV studies and research on the ATP-binding cassette families.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCE1