ABCB6 Antibody

Immunocytochemistry/Immunofluorescence: ABCB6 Antibody [NBP1-91642] - Staining of human cell line U-251 MG shows localization to the Golgi apparatus.

Immunohistochemistry-Paraffin: ABCB6 Antibody [NBP1-91642] - Staining of human testis shows cytoplasmic positivity.

• Reactivity: Hu
• Applications: ICC/IF, IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

ABCB6 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCB6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval method is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  ABCB6 Protein (NBP1-91642PEP)

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24498303)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ABCB6 Antibody

• ABC
• ABC14
• ABCB6
• ATP-binding cassette, sub-family B (MDR/TAP), member 6
• EC 3.6.3
• EST45597
• FLJ22414
• LAN
• MCOPCB7
• Mitochondrial ABC transporter 3
• mitochondrial
• MTABC3
• MTABC3ABC14
• P-glycoprotein-related protein
• PRP
• Umat

Background

"The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCB6 Antibody (NBP1-91642)(1)

Publication using NBP1-91642

• Liu H, Li Y, Hung KK et al. Genome-Wide Linkage, Exome Sequencing and Functional Analyses Identify ABCB6 as the Pathogenic Gene of Dyschromatosis Universalis Hereditaria. PLoS One 2014-01-01 [PMID: 24498303]

Bioinformatics

• Gene Symbol: ABCB6
• Entrez:
  • 10058(Human)
• Uniprot:
  • Q9NP58(Human)