5-HT2C Antibody (NLS1116)

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Immunohistochemistry-Paraffin: 5-HT2C Antibody [NLS1116] - Analysis of anti-5HT2C Receptor antibody with human pancreas, ganglion and Schwann cells.

Product Details

Summary
Reactivity Hu, Mk, Pm, Po, EqSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

5-HT2C Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT2C Receptor.
Specificity
Human 5HT2C Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Porcine (94%), Equine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HTR2C
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2.6 ug/ml

Reactivity Notes

Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Bat (81%), Panda (81%), Rabbit (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for 5-HT2C Antibody

  • 5-HT1C
  • 5-HT-1C
  • 5HT2C
  • 5-HT2C
  • 5-HT-2C
  • 5-HT2C5-hydroxytryptamine receptor 1C
  • 5-HTR2C
  • 5-hydroxytryptamine (serotonin) receptor 2C
  • 5-hydroxytryptamine receptor 2C
  • HTR1C
  • HTR2C
  • serotonin 5-HT-2C receptor
  • Serotonin Receptor 2C

Background

5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity. Expression of the 5-HT2C receptor has been reported predominantly in brain, but also in spinal cord and lung. ESTs have been isolated from human, mouse, and rat brain libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol HTR2C
Entrez