5-HT2C Products

Description

The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the beta-Arrestin family regulate receptor binding to G proteins. beta-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with betaARK (betaARK1, also designated GRK 2, or betaARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of beta- Arrestin-1 and b-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that beta-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor- mediated responses.

Bioinformatics

Entrez	3358 Human 15560 Mouse 25187 Rat
Uniprot	P28335
Product By Gene ID	3358
Alternate Names	5-HT1C 5-HT-1C 5HT2C 5-HT2C 5-HT-2C 5-HT2C5-hydroxytryptamine receptor 1C 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 5-hydroxytryptamine receptor 2C HTR1C HTR2C serotonin 5-HT-2C receptor Serotonin Receptor 2C

Research Areas for 5-HT2C

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GPCR