4-1BB/TNFRSF9/CD137 Antibody (JG1.6A)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow
Clone
JG1.6A
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

4-1BB/TNFRSF9/CD137 Antibody (JG1.6A) Summary

Immunogen
Recombinant human CD137-Fc
Specificity
NB100-64306 recognizes human CD137, an 83kD type I integral membrane protein, otherwise known as 4-1BB. The CD137 molecule is primarily expressed on activated T-cells. It is a costimulatory member of the tumour necrosis receptor family and is reported to regulate T-cell activation and proliferation.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TNFRSF9
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
Application Notes
For Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul.
Positive Control
4-1BB/TNFRSF9/CD137 Lysate (NBL1-17160)

Reactivity Notes

Cross reacts with Cynomolgus Monkey.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
TRIS buffered saline
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for 4-1BB/TNFRSF9/CD137 Antibody (JG1.6A)

  • 4-1BB ligand receptor
  • 41BB
  • 4-1BB
  • CD137 antigen
  • CD137
  • CD137MGC2172
  • CDw137
  • FLJ43501
  • ILA
  • ILAhomolog of mouse 4-1BB
  • induced by lymphocyte activation (ILA)
  • interleukin-activated receptor, homolog of mouse Ly63
  • receptor protein 4-1BB
  • T cell antigen ILA
  • T-cell antigen 4-1BB homolog
  • T-cell antigen ILA
  • TNFRSF9
  • tumor necrosis factor receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9

Background

CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for 4-1BB/TNFRSF9/CD137 Antibody (NB100-64306) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-64306AF405
Alexa Fluor 488 Labeled NB100-64306AF488
Alexa Fluor 647 Labeled NB100-64306AF647
Alexa Fluor 700 Labeled NB100-64306AF700
Allophycocyanin Labeled NB100-64306APC
DyLight 350 Labeled NB100-64306UV
DyLight 405 Labeled NB100-64306V
DyLight 488 Labeled NB100-64306G
DyLight 680 Labeled NB100-64306FR
DyLight 755 Labeled NB100-64306IR
PE Labeled NB100-64306PE
PerCP Labeled NB100-64306PCP

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Bioinformatics

Gene Symbol TNFRSF9
Entrez
Uniprot