4-1BB/TNFRSF9/CD137 Antibody (158321)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Func
Clone
158321
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

4-1BB/TNFRSF9/CD137 Antibody (158321) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse 4-1BB
Val24-Leu187
Accession # P20334
Specificity
Detects mouse 4-1BB in direct ELISAs and Western blots. In direct ELISAs, this antibody shows no cross-reactivity with recombinant mouse (rm) BAFF R, rmCD27, rmCD30, rmCD40, rmDR3, rmEDAR, rmFas, rmGITR, rmLT beta R, rmNGF R, rmOPG, rmRANK, rmTAJ, rmTNF RI, rmTNF RII, rh4-1BB, rhDR6, or rhHVEM.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TNFRSF9
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Agonist Activity
Reviewed Applications
Read 2 Reviews rated 5
using
MAB9371 in the following application:

Publications
Read Publications using
MAB9371 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 4-1BB/TNFRSF9/CD137 Antibody (158321)

  • 4-1BB ligand receptor
  • 41BB
  • 4-1BB
  • CD137 antigen
  • CD137
  • CD137MGC2172
  • CDw137
  • FLJ43501
  • ILA
  • ILAhomolog of mouse 4-1BB
  • induced by lymphocyte activation (ILA)
  • interleukin-activated receptor, homolog of mouse Ly63
  • receptor protein 4-1BB
  • T cell antigen ILA
  • T-cell antigen 4-1BB homolog
  • T-cell antigen ILA
  • TNFRSF9
  • tumor necrosis factor receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9

Background

4-1BB is a type I transmembrane protein belonging to the TNF receptor superfamily. It has been designated TNFRSF9 and is also known as CD137. 4-1BB is expressed on T cells, NK cells, monocytes, neutrophils, dendritic cells, and eosinophils. The ligand for 4-1BB, 4-1BBL, is a TNF ligand superfamily member (TNFSF9) expressed on the surfaces of activated antigen presenting cells and T and B lymphoma cell lines. 4-1BB transduces a T cell costimulatory signal to promote survival, proliferation, cytokine production, and effector function. On dendritic cells, 4-1BB ligation enhances cytokine production and upregulates expression of B7-1 and B7-2 costimulatory molecules.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for 4-1BB/TNFRSF9/CD137 Antibody (MAB9371)(4)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Agonist Activity, Control, In Vivo, Neutralization.


Filter By Application
Agonist Activity
(1)
Control
(1)
In Vivo
(1)
Neutralization
(1)
All Applications
Filter By Species
Mouse
(4)
All Species
Showing Publications 1 - 4 of 4.
Publications using MAB9371 Applications Species
E Dodagatta-, HY Ma, B Liang, J Li, DS Meyer, SY Chen, KH Sun, X Ren, B Zivak, MD Rosenblum, MB Headley, L Pinzas, NI Reed, JS Del Cid, BC Hann, S Yang, A Giddabasap, K Noorbehesh, B Yang, J Dal Porto, T Tsukui, K Niessen, A Atakilit, RJ Akhurst, D Sheppard Integrin &amp;alphav&amp;beta8 on T�cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy Cell Reports, 2021;36(1):109309. 2021 [PMID: 34233193] (In Vivo, Mouse) In Vivo Mouse
SK Ho, Z Xu, A Thakur, M Fox, SS Tan, E DiGiammari, L Zhou, M Sho, B Cairns, V Zhao, M Xiong, J Samayoa, CM Forsyth, DB Powers, DT Chao, D Hollenbaug, HM Alvarez, Y Akamatsu Epitope and Fc-mediated Crosslinking, but not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity Mol. Cancer Ther., 2020;0(0):. 2020 [PMID: 31974274] (Agonist Activity, Mouse) Agonist Activity Mouse
Wells JW, Cowled CJ, Farzaneh F Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J. Immunol., 2008;181(5):3422-31. 2008 [PMID: 18714014] (Neutralization, Mouse) Neutralization Mouse
Wu T, Xie C, Bhaskarabhatla M, Yan M, Leone A, Chen SS, Zhou XJ, Putterman C, Mohan C Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum., 2007;56(3):949-59. 2007 [PMID: 17328072] (Control, Mouse) Control Mouse

Reviews for 4-1BB/TNFRSF9/CD137 Antibody (MAB9371) (2) 52

Average Rating: 5
(Based on 2 reviews)
We have 2 reviews tested in 1 species: Mouse.

Reviews using MAB9371:
Filter by Applications
ELISA
(2)
All Applications
Filter by Species
Mouse
(2)
All Species
Images Ratings Applications Species Date Details
ELISA 4-1BB/TNFRSF9/CD137 MAB9371
Enlarge
5
reviewed by:
Verified Customer
ELISA Mouse 04/07/2019
View

Summary

ApplicationELISA
Sample TestedCOMMERCIAL ANTIGEN,M41BB ANTIGEN
SpeciesMouse
LotIMF0216091
ELISA 4-1BB/TNFRSF9/CD137 MAB9371
Enlarge
5
reviewed by:
Verified Customer
ELISA Mouse 10/16/2018
View

Summary

ApplicationELISA
Sample Testedcommercial Antigen
SpeciesMouse
LotIMF0216091

FAQs for 4-1BB/TNFRSF9/CD137 Antibody (MAB9371) (0)

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Recent Reviews

5
5
2
4
0
3
0
2
0
1
0

Verified Customer
04/07/2019
Application: ELISA
Species: Mouse

Verified Customer
10/16/2018
Application: ELISA
Species: Mouse

Bioinformatics

Gene Symbol TNFRSF9
Uniprot