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Neurodegeneration

The role of Wnts in neuroinflammation

TRPM2 expression in rat hippocampus neurons, IHC

By Michalina Hanzel, PhD

Tags: 
Alzheimer's
Neuroscience
neurodegeneration
Wnt
canonical WNT
non-canonical WNT
Wnt-5a
Frizzled
LRP5/6
beta-catenin
TCF1
LEF1
Dishevelled
RhoA
Rac
cdc42
Dkk-1
beta-amyloid
Michalina Hanzel

RNA-binding protein Staufen1 conspires with Atxn2 in stress granules to cause neurodegeneration by dysregulating RNA metabolism

PCP4 expression in mouse cerebellum Purkinje neurons, IHC

By Jamshed Arslan Pharm.D.

Tags: 
Neuroscience
Purkinje neurons
Staufen1
ATXN2
SCA2
PolyQ
Aldolase C
Pcp2
Calb1
ALS
neurodegeneration
motor deficit
Pcp4
Rgs8
Fam107b
Homer3
LC3
p62/SQSTM1
Autophagy
movement disorder

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease

Map2 and Fox3/NeuN expression in rat hippocampus, IHC

 

By Jamshed Arslan Pharm.D.

 

Tags: 
Neuroscience
neurodegeneration
Alzheimer's
Autophagy
Mitophagy
APP
amyloid beta
DRP1
Fis1/ttc11
OPA1
Mfn1
Mfn2
Pgc1-alpha
NRF1
NRF2
TFAM/mtTFA
PSD-95
Synaptophysin
MAP2
ATG5
beclin-1
LC3A
LC3B
PINK1
TERT
Bcl-2
Bnip3l
Jamshed Arslan
Western blot
Immunoblot
mAPP
Immunofluorescence

A link between Autophagy and Apoptosis: Chat with First Author Brent E. Fitzwalter

Apoptosis poster Novus Biologicals

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Apoptosis
FOXO3A
PUMA

The inflammasome: an inflammation-initiating machine, Novus Biologicals

ASC/TMS1 expression in Hela cells ICC

By Stephanie Melchor

Tags: 
IL-18
IL-1 beta
ASC/TMS1
Microglia
NLRP1
NLRP3
Caspase-1
ALS
epilepsy
Inflammation
inflammasome
Alzheimer’s
Parkinson’s
Innate Immunity
neurodegeneration
Neuroscience
immunology
Pyroptosis

How a cell "reaches" out for help

Expression of alpha-synuclein in rat neuron-glial cultures ICCchloroquine-treated, ICC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3
p62/SQSTM1
neurodegeneration
al2/SQSTM1
Parkinson's
F-actin
Lamp-1pha-synuclein
p6

Meningeal lymphatics: recent discovery defying the concept of central nervous system 'immune privilege'

Regulation Of Lymphangiogenesis Pathway Bioinformatics

By Jennifer Sokolowski, MD, PhD.

Tags: 
Meninges
CNS
Lymphatics
LYVE-1
Prox-1
CCL21/6Ckine
podoplanin
VEGF R3/Flt-4

Monitoring Autophagy in Neurons

Beclin 1 expression in human cerebellum, Purkinje cells IHC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Neuroscience
neurodegeneration
Microglia
Alzheimer's
Parkinson's
Huntington's
Bafilomycin
LC3
p62
NBR1
ATG7

MAPK Signaling Links Autophagy and Inflammation

Autophagy signaling pathway

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Neuroscience
neurodegeneration
Microglia
Alzheimer’s
Parkinson’s
ATG5
ULK1
MAPK
ERK1
p38
c-Jun
AIF-1/Iba1

Crosstalk Between Oxidative Stress and Autophagy

Autophagosome and lysosome fusion, following macroautophagy to sequester cytosolic components within the autophagosome, forms autolysosome

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3B
p62/SQSTM1
Keap1
NRF2
Glutathione Peroxidase
SOD
Western blot
ROS
RNS
redoxstasis
Gpx
Oxidative Stress
Mitophagy
Christina Towers

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