Novus Biologicals Launches New HOMER1 Antibody

Novus Biologicals recently launched a new HOMER1 antibody (catalog # NBP1-44999). This rabbit polyclonal HOMER-1 antibody has been positively validated for use in immunocytochemistry/immunofluorescence and Western blot.  It cross-reacts with human and mouse, and has 99% sequence identity to the rat protein, 98% to bovine, 96%  to Xenopus, and 74% to zebrafish.

Homer 1, short for Homer protein homolog 1, belongs to the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).

Novus' new HOMER1 antibody is available in two sizes: 0.1mL and a 25uL sample size.  The Novus antibody lab tested this antibody by Western blot on human and mouse brain lysates, achieving a band at approximately 40kDa, which can be viewed here.  Immunocytochemical detection of HOMER1 in HeLa cells using Novus' new Homer-1 antibody can be viewed here.

Novus also offers antibodies to the entire Homer family of proteinsHOMER2 and HOMER3 are post-synaptic density scaffolding proteins.  HOMER2 may couple GRM1 to PI3 kinase through its interaction with CENTG1.  Check out the Novus Explorer bioinformatic tool to browse genes, pathways, diseases and post-translational modifications that are associated with HOMER1 and other Homer proteins.


For more information on this new HOMER-1 antibody or to inquire about product collaborations, please contact the Novus Product Development Team by calling 303-730-1950 or via e-mail at

Release Date: 
Friday, August 6, 2010 - 06:00