XBP1 Antibody


Western Blot: XBP1 Antibody [NBP1-77253] - Analysis of XBP1 expression in rat liver tissue lysate with XBP1 antibody at (A) 1 and (B) 2 ug/ml.
Immunocytochemistry: XBP1 Antibody [NBP1-77253] - HepG2 cells with XBP-1 antibody at 10 ug/ml.
Immunohistochemistry-Paraffin: XBP1 Antibody [NBP1-77253] - Rat liver tissue with XBP-1 Antibody at 5 ug/mL.
Western Blot: XBP1 Antibody [NBP1-77253] - Analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide
Immunohistochemistry-Paraffin: XBP1 Antibody [NBP1-77253] - XBP1 in human liver tissue with XBP1 antibody at 5 ug/ml.
Immunohistochemistry: XBP1 Antibody [NBP1-77253] - XBP1 in mouse liver tissue with XBP1 antibody at 2 ug/ml.
Immunofluorescence: XBP1 Antibody [NBP1-77253] - XBP1 in human liver tissue with XBP1 antibody at 20 ug/ml.
Immunofluorescence: XBP1 Antibody [NBP1-77253] - XBP-1 in HepG2 cells with XBP-1 antibody at 20 ug/ml.
Immunofluorescence: XBP1 Antibody [NBP1-77253] - Rat liver tissue with XBP-1 Antibody at 20 ug/mL.

Product Details

Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, ICC/IF
1 mg/ml

Order Details

XBP1 Antibody Summary

Antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human XBP-1. The immunogen is located within amino acids 40 - 90 of XBP-1.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.5 - 2 ug/mL
  • ELISA 1:100-1:2000
  • Immunohistochemistry 5 ug/mL
  • Immunohistochemistry-Paraffin 5 ug/mL
  • Immunocytochemistry 10 ug/ml
  • Immunofluorescence 20 ug/ml
Application Notes
XBP-1 antibody can be used for the detection of XBP-1 by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL and immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
Control Peptide
XBP1 Peptide (NBP1-77253PEP)
Read Publication using
NBP1-77253 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for XBP1 Antibody

  • HTF
  • TREB5
  • X-box binding protein 1
  • X-box-binding protein 1
  • XBP1
  • XBP-1
  • XBP2
  • XBP2Tax-responsive element-binding protein 5


X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for XBP1 Antibody (NBP1-77253)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

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Secondary Antibodies


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Blogs on XBP1.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.

IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.

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Gene Symbol XBP1