WWOX Antibody

Product Discontinued

WWOX Antibody Summary

• Immunogen: Synthetic peptide: C-TEEKTQWEHPKTGK, representing the internal region of the human protein according to NP_057457.1; NP_570607.1
• Clonality: Polyclonal
• Host: Goat
• Gene: WWOX
• Purity: Immunogen affinity purified

Applications/Dilutions

• Application Notes: Peptide ELISA: antibody detection limit dilution 1:64000. Western Blot: Preliminary experiments in lysates of Human Ovary, Prostate and Testes gave no specific signal but low background (at antibody concentration up to 1ug/ml). Expected to recognise both isoform 1 (NP_057457.1) and isoform 2 (NP_570607.1). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?
• Control:

  WWOX Overexpression Lysate

Reactivity Notes

Human, Mouse, Rat, and Dog.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for WWOX Antibody

• D16S432E
• EC 1.1.1
• EC 1.1.1.-
• FOR
• FORHHCMA56
• FRA16D
• Fragile site FRA16D oxidoreductase
• SDR41C1
• short chain dehydrogenase/reductase family 41C, member 1
• WOX1
• WOX1PRO0128
• WW domain containing oxidoreductase
• WW domain-containing oxidoreductase
• WW domain-containing protein WWOX
• WWOX

Background

WW domain-containing oxidoreductase (WWOX) is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: WWOX
• Entrez:
  • 51741(Human)
• Uniprot:
  • NP_057457.1(Human)