WWOX Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	51741
Alternate Names	D16S432E EC 1.1.1 EC 1.1.1.- FOR FORHHCMA56 FRA16D Fragile site FRA16D oxidoreductase SDR41C1 short chain dehydrogenase/reductase family 41C, member 1 WOX1 WOX1PRO0128 WW domain containing oxidoreductase WW domain-containing oxidoreductase WW domain-containing protein WWOX WWOX

Research Areas for WWOX

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
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Neuroscience
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