VEGF-D Antibody (MM0007-7E79)

Images

 
Immunohistochemistry-Paraffin: VEGFD Antibody (MM0007-7E79) [NB110-60973] - Formalin fixed and Paraffin embedded human placenta tissue section was subjected to IHC staining (Proteinase K pretreatment is required).
Immunohistochemistry-Paraffin: VEGFD Antibody (MM0007-7E79) [NB110-60973] - Formalin fixed and Paraffin embedded human placenta tissue section was subjected to IHC staining using NB110-60973 (Proteinase K pretreatment ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
MM0007-7E79
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

VEGF-D Antibody (MM0007-7E79) Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human VEGF-D recombinant protein).
Specificity
VEGFD (MM0007-7E79). No cross-reactivity is shown with VEGF and VEGF-B.
Isotype
IgG2
Clonality
Monoclonal
Host
Mouse
Gene
FIGF
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
Positive Control
VEGF-D Lysate (NBL1-10722)
Publications
Read Publication using
NB110-60973 in the following applications:

  • IHC
    1 publication

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for VEGF-D Antibody (MM0007-7E79)

  • c-fos induced growth factor (vascular endothelial growth factor D)
  • FIGF
  • vascular endothelial growth factor D
  • VEGFD
  • VEGF-D
  • VEGF-DVEGFDc-Fos-induced growth factor

Background

Vascular Endothelial Growth Factor D (VEGFD), also known as c-fos-induced growth factor (FIGF), is a member of the VEGF family of growth factors. Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFD is most closely related to VEGFC (23.3% amino acid sequence identity) and has a similar VEGF homology domain that spans the middle third of the precursor protein and the long N-terminal and C-terminal extensions. In adults, VEGFD is highly expressed in lung, heart, muscle, and small intestine. VEGFD expression in fibroblasts is induced by cell interaction mediated by cadherin 11. Recombinant human VEGFD is a ligand for the tyrosine kinases, VEGFR2 (Flk1) and VEGF receptor 3 (Flt4). Since VEGFR3 is strongly expressed in lymphatic endothelial cells, it is postulated that VEGFD is involved in the regulation of the growth and/or differentiation of lymphatic endothelium and thus, a mitogen for endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VEGF-D Antibody (NB110-60973)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.


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IHC
(1)
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Human
(1)
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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol FIGF
Entrez
Uniprot