VEGF-D Antibody (MM0007-7E79) - Azide and BSA Free

Immunohistochemistry-Paraffin: VEGFD Antibody (MM0007-7E79) [NB110-60973] - Formalin fixed and Paraffin embedded human placenta tissue section was subjected to IHC staining (Proteinase K pretreatment is required).

Immunohistochemistry-Paraffin: VEGFD Antibody (MM0007-7E79) [NB110-60973] - Formalin fixed and Paraffin embedded human placenta tissue section was subjected to IHC staining using NB110-60973 (Proteinase K pretreatment is required).

• Reactivity: Hu
• Applications: WB, IHC
• Clone: MM0007-7E79
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: LYOPH

VEGF-D Antibody (MM0007-7E79) - Azide and BSA Free Summary

• Immunogen: Human recombinant VEGF-D
• Specificity: VEGFD (MM0007-7E79). No cross-reactivity is shown with VEGF and VEGF-B.
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: VEGFD
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200-1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
  • Western Blot 1:500-1:1000
• Control:

  VEGF-D Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for VEGF-D Antibody (MM0007-7E79) - Azide and BSA Free

• c-fos induced growth factor (vascular endothelial growth factor D)
• FIGF
• vascular endothelial growth factor D
• VEGFD
• VEGF-D
• VEGF-DVEGFDc-Fos-induced growth factor

Background

Vascular Endothelial Growth Factor D (VEGFD), also known as c-fos-induced growth factor (FIGF), is a member of the VEGF family of growth factors. Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFD is most closely related to VEGFC (23.3% amino acid sequence identity) and has a similar VEGF homology domain that spans the middle third of the precursor protein and the long N-terminal and C-terminal extensions. In adults, VEGFD is highly expressed in lung, heart, muscle, and small intestine. VEGFD expression in fibroblasts is induced by cell interaction mediated by cadherin 11. Recombinant human VEGFD is a ligand for the tyrosine kinases, VEGFR2 (Flk1) and VEGF receptor 3 (Flt4). Since VEGFR3 is strongly expressed in lymphatic endothelial cells, it is postulated that VEGFD is involved in the regulation of the growth and/or differentiation of lymphatic endothelium and thus, a mitogen for endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VEGF-D Antibody (NB110-60973)(1)

Publication using NB110-60973

• Schimanski CC, Schlaegel F, Jordan M et al. VEGF-D correlates with metastatic disease in gastric cancer patients undergoing surgery World J Surg 2011-05-01 [PMID: 21387130] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: VEGFD
• Entrez:
  • 2277(Human)
• Uniprot:
  • O43915()